Designed especially for neurobiologists, FluoRender is an interactive tool for multi-channel fluorescence microscopy data visualization and analysis.
Deep brain stimulation
BrainStimulator is a set of networks that are used in SCIRun to perform simulations of brain stimulation such as transcranial direct current stimulation (tDCS) and magnetic transcranial stimulation (TMS).
Developing software tools for science has always been a central vision of the SCI Institute.

Events on May 6, 2024

Rachaell Nihalaani Presents:

Uncertainty Estimation and Analysis in 3D Anatomy Segmentation

May 6, 2024 at 9:00am for 1hr
Evans Conference Room, WEB 3780
Warnock Engineering Building, 3rd floor.

Abstract:

In 3D anatomy segmentation, fully supervised methods are recognized for their precision but are constrained by the limited availability of detailed annotated datasets. This has catalyzed interest in alternative approaches that lessen the dependency on extensive labeled data, such as semi-supervised and self-supervised methods, which effectively leverage the abundant unannotated data. Among these, slice propagation is a notable self-supervised method that utilizes slice registration to facilitate comprehensive anatomy segmentation with minimal direct oversight, significantly reducing the necessary resources in terms of time, cost, and expert involvement for annotating datasets.
Nevertheless, adopting less supervised methodologies using deterministic networks presents a dilemma: it potentially compromises the predictability and accuracy seen with full supervision. To explore this trade-off, our study integrates calibrated uncertainty quantification (UQ) across a spectrum of supervision levels—from fully supervised to semi-supervised and self-supervised models. This integration not only seeks to enhance trust in these less supervised models but also to assess their practical utility thoroughly.
Our empirical investigations, conducted across six datasets for 3D abdominal segmentation using five different UQ techniques, illustrate that including UQ not only fortifies the trustworthiness of the models across different supervisory schemes but also contributes to a nuanced understanding of their segmentation accuracy. Additionally, our analysis identifies specific limitations of each supervisory approach, particularly highlighting how slice propagation might conceal critical failure modes not immediately obvious to users. This comparative study thereby advances our comprehension of the trade-offs between the degree of supervision and the resulting uncertainty, paving the way for more refined and reliable 3D anatomy segmentation methodologies.

Posted by: Nathan Galli

Janmesh Ukey Presents:

Towards a Fully Automated Framework for Statistical Shape Modeling from Images

May 6, 2024 at 10:00am for 1hr
Evans Conference Room, WEB 3780
Warnock Engineering Building, 3rd floor.

Zoom: https://utah.zoom.us/j/95795634386 Meeting ID: 957 9563 4386 Passcode: 352796

Abstract:

Statistical Shape Modeling (SSM) is a potent tool for analyzing anatomical differences across populations. It yields both population-wide and subject-specific shape statistics, offering valuable insights into anatomical variation. However, deep learning methods, while capable of extracting shape information directly from unsegmented images, face challenges such as the need for manual segmentations in training, as well as pre-processing requirements during both training and inference phases. Existing deep learning approaches also often focus solely on population-level shape statistics, neglecting subject-level shape statistics. We aim to address these limitations by mitigating the supervision bottleneck in training and inference phases for deep learning-based shape modeling methods. Firstly, we identify the need for improved automation in the localization of anatomies and consideration of rigid pose information. To this end, we introduce a novel deep learning framework tailored for anatomy localization and rigid alignment, which significantly enhances accuracy compared to previous approaches. Moreover, recognizing the importance of subject-level shape statistics and the challenge of handling multiple anatomies simultaneously, we present a novel framework enabling the prediction of both subject-level and population-level shape statistics for multiple anatomies within a single image. Our research highlights the significance of subject-level shape statistics in providing superior shape information, outperforming segmentation methods in medical imaging tasks. Despite advancements in automation during inference, the manual segmentation requirement during training remains a bottleneck. Therefore, we delve into investigating weakly supervised segmentation methods as potential alternatives. Through comprehensive qualitative and quantitative evaluations, we aim to determine whether these methods can alleviate the need for manual segmentation, thereby enhancing automation and efficiency in shape modeling pipelines.

Posted by: Nathan Galli